Study LSD legally with 1V-LSD (VALERIE)

Here at Realchems, we take pride in being one of the most up-do-date sources for research chemicals. Chemists, researchers and scientists from all over the world rely on us for providing them with a selection of different research chemicals so that they can continue their study.

As such, we wouldn’t be doing anyone any favors if we weren’t stocking the newest legal derivative of LSD. 1V-LSD, known also as Valerie due to the compound’s chemical name (1-valeroyl-lysergic acid diethylamide), is undoubtedly going to be a massively popular research chemical.

It shares a lot of striking similarities with LSD. As a research chemical, Valerie LSD allows researchers to basically study LSD despite the fact that it is not legal to obtain.

With amounts similar to what researchers would expect to see with regular LSD (around 150mcg of concentration), Valerie LSD is similar in all regards. This blog post will go on to describe how and why these products should be studied by those who are interested in the study of psychedelic tryptamines.

What Is 1V-LSD?

1-valeroyl lysergic acid diethylamide, also known as 1V-LSD or simply Valerie, is a psychedelic research chemical. The compound shares a huge amount of similarities with regular LSD (lysergic acid diethylamide).

As you can see from the chemical names, 1V-LSD contains LSD as a core component. This means that it will work to provide similar effects. 1V-LSD is considered a prodrug of LSD.

1V-LSD emerged partly in response to a change in legislation that affected Germany. An update in the NPsG has made it illegal to possess any previously-synthesized lysergamides. This led researchers to scramble quickly to develop the newest legal derivative of LSD so that chemists could continue their valuable research on this therapeutic class of compounds.

What Is a Prodrug?

A prodrug is a compound that may or may not be inert on its own. However, it has the capacity to be converted easily by metabolism into a pharmacologically active compound. This allows researchers to study compounds that would otherwise be challenging to administer due to either pharmacological or legislative concerns.

In the pharmaceutical industry, prodrugs are often designed to help enhance the bioavailability of certain compounds that are otherwise challenging to metabolize. In the research chemical community, prodrugs can be useful because they allow scientists to study compounds that would otherwise be unavailable or hard to obtain.

Prodrugs have been used for centuries by many different communities and cultures. For example, plant sugars known as glycosides have typically been used for this purpose. Glycosides are converted in the digestive tract into a compound known as aglycone which is a more bioavailable source of energy.

Prodrugs like 1V-LSD can be converted into active compounds both in vivo and in vitro, given that the proper enzymes or chemicals are available to produce the necessary reactions. Other lysergamides, such as 1cP-LSD and 1P-LSD, are also considered prodrugs of LSD.

1V-LSD Chemistry

1-valeroyl-LSD is not that much different than LSD, so researchers who are familiar with LSD will probably know what to expect with this compound. Other prodrug lysergamides, such as 1cP-LSD and 1B-LSD, function in a similar manner.

Living organisms possess the necessary enzymes and chemicals required to catalyze the reaction that turns 1V-LSD into regular LSD. However, researchers can also create these changes in vitro with the proper enzymes. 

The name “Valerie” is derived from 1-valeroyl-lysERgic acid dIEthylamide, in a similar manner that LSD derived its original name from the german chemical name. If you’re looking for a German legal 1V-LSD for sale then you’ll have no problem finding a product in the next few months.

1V-LSD is the N-valeroyl derivative of LSD. The valeroyl compounds are highly lipophilic, meaning that they can be absorbed relatively easily into fat cells. This lipophilic nature is different than what researchers are used to with typical LSD-based compounds and opens up a whole new realm of possibilities for therapeutic study. 

Though we do not fully understand the ramifications of these pharmacokinetic changes, researchers remain content in saying that 1V-LSD shares similar properties with LSD. The lipophilic nature does not change much of the end results, instead, simply makes it easier to transmit across lipid barriers.

Differences and Similarities of Valerie LSD

Many of the LSD prodrugs are more similar than they are different, and Valerie is not much different. That said, there are some things that you should know. It’s not exactly identical to LSD (otherwise it would be the same chemical), and the differences are what makes this research chemical fascinating to study.

Those who have already had the opportunity to research 1V-LSD report that it shares the most similarities with 1cP-LSD. This makes sense considering they are both direct prodrugs of LSD. However, considering a large number of prodrugs available wouldn’t it make sense that they all have the exact same effects?

This would make things simpler but it’s not always the case. These prodrugs have different molecular weights and thus can take different amounts of time to be processed. The result of this is that research effects and conclusions can vary a bit depending on how these substances are processed. 

Valerie LSD has a higher molecular mass than many of the other LSD-based research chemicals that are currently available. Its higher mass results in a slight decrease in potency; most scientists recommend researching with a starting dose of 125 mcg of 1cP-LSD whereas 150 mcg of 1V-LSD is recommended.

One of the other most noticeable differences between 1V-LSD and other similar research compounds is the price. Because 1V-LSD is a bit more challenging to synthesize, largely due to issues with crystallization, the amount of effort involved is more costly. Furthermore, the increase in the physical dose required for research leads to an increase in price.


1V-LSD, or simply Valerie, is the most recent derivative of LSD. It was produced in response to a German law that made it illegal to possess prior LSD analogs and prodrugs. Fortunately, 1V-LSD is entirely legal and shares pretty much the same properties as these other substances.

If you are eager to continue your research on psychedelic lysergamides then don’t hesitate to try out our 1V-LSD.

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